Osteoarthritis (OA), which is a progressive degenerative
chronic disease, can cause joint stiffness, swelling, pain and loss of mobility,
characterized by cartilage and synovial inflammation.1 A high
prevalence of OA is seen mainly in elderly population (85% of above 65 years of
age worldwide).3 Although there is no chance of
full recovery from OA, primary management of OA is done by prescribing analgesics
and non steroidal anti inflammatory drugs (NSAIDs) to reduce the symptoms
(pain, stiffness etc).3 But a prolonged use of pharmacological
agents leads to substantial gastrointestinal, renal, and cardiovascular side
effects. So, as alternative therapy nutraceuticals and supplements are on the


The term ‘nutraceutical’ was developed
from ‘nutrition’ and ‘pharmaceutical’ in 1989 by DeFelice and was originally
defined as ‘a food (or part of the food) that provides medical or health
benefits, including the prevention and/or treatment of a disease.2 Some of the most
commonly used nutraceuticals in joint pathology include glucosamine,
chondroitin sulfate, Hyaluronic acid, krill oil, fish oil, turmeric, gamma
linolenic acid and avocado-soybean unsaponifiables. 4
studies indicate that the other natural compounds like phytoflavonoids,
polyphenols, and bioflavonoids, which are found in fruits, teas, spices, wine,
and vegetables, have shown the most potential to modify OA disease and symptoms
based on their anti-inflammatory and anti-catabolic actions, and protective
effects against oxidative stress.6

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This is well proved that neutraceuticals   improve cartilage health, but still
preclinical studies are still required for analyzing the activity of
nutraceutical products. As
a result neutraceuticals
were extensively
studied in in vivo efficacy studies which demonstrated significant
anti?inflammatory activity in acute and chronic inflammatory. The review
objective is to disscuss the commonly used neutraceticals including their role
in OA in brief and the preclinical studies which are done to prove the
effectivity of these agents.


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