MSP2, is the second importantGPI anchored merozoite surface protein with approximately 25 kDa  (Gilson et al., 2006).

Another leading candidate is MSP2 antigen subunit of P. falciparum formalaria vaccine (Happi et al., 2004).It consists of highly polymorphic central repeats flanked with conserved N- andC-terminal domains unique variable domains. The MSP-2 has generally two allelestypes, FC27 and 3D7, with different dimorphic structure considerably of thevariable central region, block-3 . The specific region of strains is consistsof repeating units; 3D7 allele  containrepeating units of Ser, Gly and Ala, while FC27 allelic  forms contain 32-, 12- and 8-mer sequencerepeats. Both allelic forms of MSP2 are basically unstructured, but full lengthrecombinant proteins under physiological conditions make fibrils (Adda etal.

, 2009). Fibril development is mediated through the region of N-terminal(Low et al., 2007) and this region may also have the properties membraneinteraction(Zhang et al. 2008).

It is called whether native fibril likeform of  MSP2 or other complexes;however, there is some evidence that MSP2 oligomers are placed on merozoitessurface with a number of  MSP-2interactions molecules being hypothesized (Yang et al., 2010). Recentstudies recommend that the MSP-2, N-terminal region may interact with the lipidmembrane of the merozoite surface (MacRaild et al,. 2012 ; (Adda etal., 2009)). MSP2 appears to be important for invasion and during invasion retainedon the surface and  soon after degraded wheninvasion is complete. However, its exact character is unknown, and no interactionof receptor ligand or fixing of MSP2 to RBCs have been defined.

 MSP-1 andMSP- 2 genes  because of polymorphiccharacters  have been characterized aspolymorphic markers in studies of malaria transmission dynamics in naturalisolatesof P. falciparum (Ferreiraet al., 2007 ; (Boyle et al., 2014)


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