The analogy of the relationshipof the upper motor neuron and the lower motor neuron is like the planner anddoer framework. The architect of the movement is the upper motor neuron, whilethe doer of the movement is the lower motor neuron.The thinking process occursin the cortex of the cerebrum, the home of the upper motor neurons whichjourneys down to the spinal cord. Lower motor neurons actas the signal conduit between the upper motor neurons and the skeletal musclesto be innervated.

 The upper and lower motor neuron are linkedwith interneurons in the spinal cord and hence lower motor neurons originate inthis region and extend to the muscle.  2. Astrocytesare multi-taskers as they perform diverse roles from logistical support thruthe shipment of nutrients, juggling the correct ion concentration andreconstruction during neuronal damage. Due to the core function of astrocytewith repair and maintenance, reactive astrongliosis as response to injury andinfection is a hallmark feature of CNS disturbance. Microglia is Cookie Monster of the central nervous system thedevourer of plaques, injured  neurons and synapses and pathogens in the central nervous system. The antipodal extremes of low activity (Autism) to over activity (Alzheimer’s)produces pathological effects.  Oligodendrocytes produces myelinsheath to coveraxons as insulation in the central nervous system.

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Lack of myelination occurswhen oligodendrocytes die, and unmyelinated neurons cannot function properly asseen in multiple sclerosis. 

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